b-Cyclodextrin (b-CD) is widely used to increase the stability, solubility, and bioavailability of poorly soluble drugs because of the appropriate size of its cavity. Cefuroxime axetil is beta lactum antibiotic having poor water solubility. Here we report the complexation of cefuroxime axetil base with b-CD and the stability, dissolution, and pharmacokinetic properties of the cefuroxime axetil/CD complex. The formation of cefuroxime axetil/b-CD inclusion complexes is confirmed using differential scanning calorimetry, X-ray diffractometry. The thermal and photochemical stability of cefuroxime axetil is significantly improved by the complexation with b-CD, Our study suggests that cefuroxime axetil/b-CD complexation can be of great use to increase the stability and biological efficacy of cefuroxime axetil base.
Loading....